Intern

2025 Summer Intern – Discovery Oncology

Department Summary

Different groups in the Discovery Oncology Department work on identifying critical proteins and pathways important for controlling tumor cell growth and death. In addition we work on establishing potential therapeutics that activate or inhibit these pathways in cancer cells. We also investigate molecular mechanisms which regulate sensitivity and resistance to targeted agents to understand drug response in the context of heterogeneity of cancer cells and patients.

This internship position is located in South San Francisco, onsite

The Opportunity

This lab works on Antibody-Drug Conjugates (ADCs) as a modality of targeted therapy for different types of cancers. We focus mainly on breast cancer and certain hematologic malignancies. We are looking for an individual with strong cell biology and biochemistry skills to participate in one of our ADC programs. The individual will be responsible for:

• Maintaining and expanding cell lines for use in in vitro assays
• Assessing expression of cell surface targets on cancer cells
• Measuring binding of ADCs to specific targets on cancer cells
• Testing different ADCs and small molecule compounds in cell proliferation and apoptosis assays
• Participating in lab and team meetings to share data

Program Highlights

• Intensive 12-week, full-time (40 hours per week) paid internship.
• Program start dates are in May/June (Summer)
• A stipend, based on location, will be provided to help alleviate costs associated with the internship.
• Ownership of challenging and impactful business-critical projects.
• Work with some of the most talented people in the biotechnology industry.

Who You Are

Required Education

You meet one of the following criteria:

• Must be pursuing a Bachelor’s Degree (enrolled student).
• Must have attained a Bachelor’s Degree (not currently enrolled in a graduate program).
• Must be pursuing a Master’s Degree (enrolled student).
• Must have attained a Master’s Degree.
• Must be pursuing a PhD (enrolled student).
• Must have attained a PhD.

Required Majors:Cell/Molecular Biology, Biochemistry, Pharmacology

Required:

• Extensive experience in mammalian cell culture (both adherent cells and suspension cells)
• Counting cells and plating/seeding cells for experiments in 96-well plates
• Assessing proliferation/apoptosis using provided kits
• Assessing expression of cell surface proteins by flow cytometry
• Proficiency in MS Powerpoint/Word/Excel
• Mammalian cell culture: making cell culture medium, maintaining, expanding and freezing down cells
• Ability to count cells and set up proliferation/apoptosis assays with different concentrations/dilutions of ADCs, antibodies and small molecule compounds
• Ability to measure cell surface proteins by either flow cytometry or immunoblot
• Data analysis and graphing
• Making Powerpoint presentations of data/project outcomes

Preferred:

• Biochemical methods such as western blot
• Knowledge of graphics programs such as Prism, Kaleidagraph
• Excellent communication, collaboration, and interpersonal skills.
• Complements our culture and the standards that guide our daily behavior and decisions: Integrity, Courage, and Passion.

Relocation benefits are not available for this job posting.

The expected salary range for this position based on the primary location of STATE is $25-$45 hour. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. This position also qualifies for paid holiday time off benefits.

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Genentech is an equal opportunity employer, and we embrace the increasingly diverse world around us. Genentech prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status.

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